Biomimetic 3D-printed neurovascular phantoms for near-infrared fluorescence imaging

Geometrically complex 3D-printed phantoms for diffuse optical imaging

Tissue-equivalent phantoms that mimic the optical properties of human and animal tissues are commonly used in diffuse optical imaging research to characterize instrumentation or evaluate an image reconstruction method. Although many recipes have been produced for generating solid phantoms with specified absorption and transport scattering coefficients at visible and near-infrared wavelengths, t...

Tissue-simulating phantoms for assessing potential near-infrared fluorescence imaging applications in breast cancer surgery.

Inaccuracies in intraoperative tumor localization and evaluation of surgical margin status result in suboptimal outcome of breast-conserving surgery (BCS). Optical imaging, in particular near-infrared fluorescence (NIRF) imaging, might reduce the frequency of positive surgical margins following BCS by providing the surgeon with a tool for pre- and intraoperative tumor localization in real-time....

Validation of near infrared spectroscopic (NIRS) imaging using programmable phantoms

For much of the past decade, we have developed most of the essential hardware and software components needed for practical implementation of dynamic NIRS imaging. Until recently, however, these efforts have been hampered by the lack of calibrating phantoms whose dynamics substantially mimic those seen in tissue. Here we present findings that document the performance of a dynamic phantom based o...

Near-Infrared Fluorescence Optical Imaging and Tomography

The advent of recent advances in near-infrared laser diodes and fast electro-optic detection has spawned a new research field of diagnostic spectroscopy and imaging based on targeting and reporting exogenous fluorescent agents. This review seeks to concisely address the physics, instrumentation, advancements in tomography, and near-infrared fluorescent contrast agent development that promises s...

Evaluation of Reflection Optical Imaging Characteristics Using Fluorescence with Near Infrared Wavelength at Different Depths of Tissue Equivalent Phantom